At 11:50am on 15 October 1970, a 112 metre span of the partially constructed bridge collapsed, taking the lives of 35 construction workers and leaving 18 others seriously injured.
The collapse was a turning point for occupational health and safety in Victoria.
WorkSafe Chief Executive Colin Radford said the anniversary was a reminder that we must continually strive to make workplaces safe.
"For those who worked on the West Gate Bridge, the memories of its collapse and the suffering that followed are as vivid as ever," Mr Radford said.
"While we've come a long way in improving workplace health and safety and the support we can provide for injured workers and their families, nothing can ever replace a loved one who went to work one day and didn't come home."
Mr Radford extended his condolences to the families, friends and workmates of the 35 men who died and acknowledged the enduring legacy of their sacrifice.
"The bridge is a lasting reminder to all of us that the most important reason for keeping workplaces safe, are the people waiting at home."
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